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MSDS Number: A7750 * * * * * Effective Date: 03/15/06 * * * * * Supercedes: 02/12/04
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AURAMINE O
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1. Product Identification
Synonyms: Auramine O, biological stain; CI 41000; aniline,4,4'-(imidocarbonyl)bis(N,N-dimethyl-, hydrochloride; Auramine hydrochloride; CI basic yellow #2
CAS No.: 2465-27-2
Molecular Weight: 303.84
Chemical Formula: C17H21N3ClH
Product Codes:
J.T. Baker: B604
Mallinckrodt: E056
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2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------------ ---------
Aniline, 2465-27-2 100% Yes
4,4'-(imidocarbonyl)bis(N,N'-bimethyl-,
hydrochloride)
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3. Hazards Identification
Emergency Overview
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WARNING! HARMFUL IF SWALLOWED OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 2 - Moderate
Flammability Rating: 1 - Slight
Reactivity Rating: 0 - None
Contact Rating: 2 - Moderate (Life)
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Green (General Storage)
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Potential Health Effects
----------------------------------
There is limited information on the human health effects from exposure to this substance.
Inhalation:
No information found, but compound should be handled as a potential health hazard. May cause irritation to the respiratory tract. Symptoms may include coughing, sore throat, labored breathing, and chest pain.
Ingestion:
No information found, but animal studies indicate substance is toxic.
Skin Contact:
May cause irritation with redness and pain. Animal studies indicate substance is toxic by skin absorption.
Eye Contact:
May cause irritation, redness and pain.
Chronic Exposure:
A related compound (auramine, CAS# 492-80-8) has been shown to cause cancer in animals and may be linked to cancer in humans.
Aggravation of Pre-existing Conditions:
No information found.
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4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
Ingestion:
Give large amounts of water to drink. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Call a physician.
Eye Contact:
In case of contact, immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Call a physician if irritation persists.
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5. Fire Fighting Measures
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
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6. Accidental Release Measures
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container.
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7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Separate from incompatibilities. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
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8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Use chemical safety goggles.
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9. Physical and Chemical Properties
Appearance:
Yellow needles.
Odor:
No information found.
Solubility:
Soluble in water.
Specific Gravity:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
No information found.
Melting Point:
267C (513F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
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10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
May produce carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers.
Conditions to Avoid:
Incompatibles.
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11. Toxicological Information
Toxicological Data:
Oral mouse LD50: 480; mg/kg Skin mouse LD50:300 mg/kg; investigated as a mutagen, tumorigen.
Carcinogenicity:
This substance is not listed as a carcinogen by NTP or IARC. However, a related substance (auramine, CAS# 492-80-8) is listed as an IARC 2B (IARC 1 for manufacturing) carcinogen.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Aniline, No No None
4,4'-(imidocarbonyl)bis(N,N'-bimethy
l-, hydrochloride) (2465-27-2)
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12. Ecological Information
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.
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13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
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14. Transport Information
Not regulated.
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15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Aniline, Yes Yes Yes Yes
4,4'-(imidocarbonyl)bis(N,N'-bimethyl-,
hydrochloride) (2465-27-2)
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Aniline, Yes Yes No Yes
4,4'-(imidocarbonyl)bis(N,N'-bimethyl-,
hydrochloride) (2465-27-2)
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Aniline, No No No No
4,4'-(imidocarbonyl)bis(N,N'-bimethyl-,
hydrochloride) (2465-27-2)
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Aniline, No No No
4,4'-(imidocarbonyl)bis(N,N'-bimethyl-,
hydrochloride) (2465-27-2)
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
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16. Other Information
NFPA Ratings: Health: 2 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
Label Precautions:
Avoid breathing dust.
Avoid contact with eyes, skin and clothing.
Keep container closed.
Use with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
If swallowed, give large amounts of water to drink. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. In all cases, get medical attention.
Product Use:
Laboratory Reagent. Dye / Stain
Revision Information:
MSDS Section(s) changed since last revision of document include: 3, 16.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.) MSDS
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